Arginine Amino Acid & Omega Fatty Acid (etc. Omega 3, 6) in Oral/ Dental Health Care
Carious lesions develop in tooth surfaces where there is an imbalance of the processes of acid and alkali production by supragingival biofilms. Since low pH is the main driving factor in the development of carious lesions, most efforts to identify an effective anticaries therapy have focused on targeting the acid-producing bacteria and their mechanisms of acid production. An expanding area of oral microbiology has now been devoted to explore microbial metabolic activities that help to neutralize biofilm pH and thus inhibit the caries process. Arginine metabolism via the arginine deiminase pathway (ADS) produces alkali in the form of ammonia that counteracts the effects of biofilm acidification from bacterial glycolysis. ADS also functions as an adaptive strategy used by certain bacteria to thrive in oral biofilms. Substantial evidence accumulated from laboratory and clinical observations supports the hypotheses that measurements of arginine metabolism via ADS may serve as an important caries risk assessment criterion and that providing arginine regularly to supragingival biofilms can be an effective therapy for caries intervention. The potential of arginine-based therapies such as the use of arginine as prebiotic, ADS+ strains as probiotics, and oral care formulations containing arginine for prevention and management of dental caries.
Potential Uses of Arginine in Dentistry: 1. reviewed in Nascimento, 2018 , 2. Bowen et al., 2018 , 3. Chakraborty and Burne, 2017 , 4. Astvaldsdottir et al., 2016; Richards, 2017 , 5. Agnello et al., 2017; Huang et al., 2017; Zheng et al., 2017 , 6. Slomka et al., 2017, 2018
Omega 3, 6 and Oral/ Dental Health Care
Omega-3 and Omega-6 Fatty Acids Act as Inhibitors of the Matrix Metalloproteinase-2 and Matrix Metalloproteinase-9 Activity relation to Periodontal Therapy and Dental Caries Control
Polyunsaturated fatty acids have been reported to play a protective role in a wide range of diseases characterized by an increased metalloproteinases (MMPs) activity. The recent finding that omega-3 (ω-3) and omega-6 (ω-6) fatty acids exert an anti-inflammatory effect in periodontal diseases has stimulated the present study, designed to determine whether such properties derive from a direct inhibitory action of these compounds on the activity of MMPs. To this issue, we investigated the effect exerted by omega-3 and omega-6 fatty acids on the activity of MMP-2 and MMP-9, two enzymes that actively participate to the destruction of the organic matrix of dentin following demineralization operated by bacteria acids. Data obtained (both in vitro and on ex-vivo teeth) reveal that omega-3 and omega-6 fatty acids inhibit the proteolytic activity of MMP-2 and MMP-9, two enzymes present in dentin. This observation is of interest since it assigns to these compounds a key role as MMPs inhibitors, and stimulates further study to better define their therapeutic potentialities in carious decay.
Our findings suggest that ω-3, 6 FAs can successfully reduce gingival inflammation, pocket depth, and attachment level gain. Dietary supplementation and topical administration with ω-3, 6 FAs may have potential benefits as a host modulatory agent in the prevention and/or adjunctive management of chronic periodontitis.
From many studies have shown that omega-3s can drastically reduce the signs of periodontal disease. A diet rich in DHA and EPA omega-3s, whether through supplementation or as part of regular dietary choices, can help maintain gum health and keep teeth securely rooted, preventing tooth decay that can often form in the spaces between damaged gums and the tooth itself.
+พยาธิวิทยาภูมิคุ้มกันของโรคปริทันต์ ( Immunopathology of Periodontal Disease ), บทบาทของสารตัวกลางจากภูมิคุ้มกันที่เป็นมาแต่กำเนิดในโรคปริทันต์, The Role of Mediators from Innate Immunity in Periodontal Disease, สุทธิชัย กฤษณะประกรกิจ, พัทนินทร์ มนตรีขจร และคณะ
+Omega 3 fatty acids and periodontitis in U.S. adults, Asghar Z. Naqvi, MD, MPH, MNS, Catherine Buettner, MD, MPH, Russell S. Phillips, MD, Roger B. Davis, ScD, and Kenneth J. Mukamal, MD, MPH, MA,
+Effect of Omega 3 on Periodontitis in Postmenopausal Women
+Omega-3 Fatty Acids For Periodontal Health: An Update
October 1, 2014
by David W. Dodington, BSc (Hons), MSc; Peter C. Fritz, BSc, DDS, FRCD(C), PhD (Perio), Certified Specialist in Periodontics; Wendy E. Ward, B. Arts & Sci. (Hons), MSc, PhD.