Skin Maintainance with Various Natural Enhancement from Natural Source
Enhancement of mechanisms in regulation of skin homeostasis has become novel emerging approaches for skin therapy as well as cosmeceutical targets. As human epidermis always has tissue turnover in response to damage or ageing, the ongoing renewal process is required for sustaining a balance status and functions of skin. Maintaining the stemness is the key to preserve our skin function as long as possible.
Epidermal stem cells are the key maintaining epidermal homeostasis via the cell renewal process and cytokine production. As we aged, it is hard to avoid the condition of age-associated inflammation skin. In that situation, activities and amounts of epidermal stem cells were found to be dramatically reduced. As evidence indicating that the stem cells not only acts as a new cell reservoir for regeneration, but they also produce a number of cytokines and growth factors supporting skin functions. Thus, the decrease of stem cells function and population from age-associated inflammation skin would deteriorate skin function. So, if we could distinguish the agents that are the stemness booster and might could preserve our skin function. It could be a strategy to solve this problem.
Natural active agents that regulate stemness of keratinocytes, natural product derived vanillin is of interest. Vanillin is the primary aromatic agents, isolated from vanilla cured beans. Vanillin is as an anticlastogen, from its properties to suppress gene mutations in both bacterial and mammalian cells. In addition, it was found that vanillin has the ability in protection of human single cell DNA from oxidative attack. In 2014, Lee et. al found that vanillin could protect human keratinocyte stem cells against ultraviolet B irradiation. These characteristics suggest vanillin as an interesting agent to apply its potency in improving stemness in keratinocytes and in various skin. Beside, vanillin has a potential to increase cell-cell cohesion and stemness in human keratinocyte cells. Cell-cell cohesion is essential for skin barrier function, being strength niches and benefit stem cell property. As the stemness of
keratinocytes is an important factor determining the function of epidermis as well as it regeneration processes, vanillin may be a potential candidate for enhancement of the
skin protective and repair functions.
MOLECULAR BIOLOGY EFFECTS OF VANILLIN ON KERATINOCYTES, BY MISS SUPAK TABOONPONG, A THESIS SUBMITTED IN PARTIAL FULFILLMENT OF THE REQUIREMENTS FOR THE DEGREE OF MASTER OF SCIENCE (DERMATOLOGY) CHULABHORN INTERNATIONAL COLLEGE OF MEDICINE THAMMASAT UNIVERSITY
ACADEMIC YEAR 2016 COPYRIGHT OF THAMMASAT UNIVERSITY