Principle of Wound Management and Wound Bed Preparation

Last updated: Aug 21, 2019  |  1249 Views  |  Wound

Principle of Wound Management and Wound Bed Preparation

Wound healing begins as soon as the injury occurs. The four phases of wound healing
are described as hemostasis, inflammation, proliferation, and remodeling. During the
inflammation phase of wound healing neutrophils and cytokines produce oxidants,

such as reactive oxygen species (ROS) or reactive nitrogen species (RNS). Thesesubstances act as free radicals, a highly reactive species that steals electrons fromneighboring molecules to satisfy its valence electron needs. This removal of electronscan delay wound healing or produce significant damage within the healthy cells oftissues throughout the body. In response to the oxidative stress occurring at the woundsite, antioxidants can be used to quench free radicals and reestablish the necessaryenvironment for wound healing. Antioxidants act by donating electrons
to the free radicals, sparing the damaging effects of an oxidation reaction on othermolecules and tissues. Therefore, through the promotion of adequate antioxidant intakethroughout the wound healing process it is possible to facilitate healthy tissue and to improve the healing outcome.

The natural antioxidants frequently cited in literature pertaining to nutrition and wound healing include: Vitamin E, Linoleic Acid, Alpha-Linolenic Acid, Alpha-Lipoic Acid, Curcumin, Vitamin C, Natural Vanillin, Grape Seed Extract, Coenzyme Q10, and Lutein; all of which promote the development of new tissue in wounds by reducing the concentration of free radicals. In addition to their antioxidative capabilities, each of
these compounds contributes to the process of wound healing in unique ways. Thus, these compounds have the potential to provide physiological relief to patients suffering from all injuries. ....



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